Tacrolimus Impurity 28 CAS 133941-75-0
| CAS No. | 133941-75-0 |
| Molecular Formula | C56H97NO12Si2 |
| Molecular Weight | 1032.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tacrolimus Impurity 28 (CAS 133941-75-0, C56H97NO12Si2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C56H97NO12Si2, Tacrolimus Impurity 28 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 1032.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tacrolimus Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C56H97NO12Si2 |
| Molecular Weight | 1032.54 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus Impurity 24 (CAS 1356352-20-9)
- Tacrolimus Impurity 25 (CAS 1356932-17-6)
- Tacrolimus Impurity 27 (CAS 104987-25-9)
- Tacrolimus Impurity 40 (CAS CATO-C4X-130040)
- Tacrolimus Impurity 41 (CAS CATO-C4X-130041)
- Tacrolimus Impurity 42 (CAS CATO-C4X-130042)
- Tacrolimus impurity 49 (CAS CATO-C4X-130049)
- Tacrolimus impurity 50 (CAS CATO-C4X-130050)
Recommended Standards
- 37-Desmethylene 24,33-Bis-O-(tert-butyldimethylsilyl)-37-oxo-FK-506 (CAS 155684-96-1)
- (SP-4-1)-[1,8,15,22-Tetrakis[2-methyl-1-(1-methylethyl)propoxy]-29H,31H-phthalocyaninato-N29,N30,N31,N32]coppe (CAS 144843-25-4)
- Lys-[Des-Arg9]-Bradykinin (CAS 71800-36-7)
- [Asu1,6,Arg8] Vasopressin (CAS 40944-53-4)
- Papaverine Impurity 34 (CAS 41498-25-3)
- Pitavastatin Impurity 42 (CAS CATO-C4X-103742)
- Evocalcet Impurity 31 (CAS CATO-C4X-248531)
- 3-Iodo-N-(pyridin-2-ylmethyl)aniline (CAS 1152559-97-1)
- Racemic-(1S,3S,4S,5R)-2-(Tert-Butoxycarbonyl)-5-Fluoro-2-Azabicyclo[2.2.1]Heptane-3-Carboxylic Acid (CAS 1272757-14-8)
- 5-Bromo-1-tert-butyl-6-fluoro-2-methyl-1,3-benzodiazole (CAS 1403483-76-0)
- Avibactam Impurity 139 (CAS CATO-C4X-1348139)
- 2,3-Dihydrobenzo[b][1,4]dioxine-6,7-diamine dihydrochloride (CAS 73448-02-9)
- Famotidine Impurity 45 (CAS 1644079-90-2)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com