4-(3-Chloro-5-fluorophenyl)aniline CAS 1345471-96-6

Description

The occurrence of 4-(3-Chloro-5-fluorophenyl)aniline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-(3-Chloro-5-fluorophenyl)aniline (CAS 1345471-96-6) is a high-purity analytical reference standard with the molecular formula C12H9ClFN and a molecular weight of 221.66 g/mol.

The molecular framework of 4-(3-Chloro-5-fluorophenyl)aniline (C12H9ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-(3-Chloro-5-fluorophenyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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