Bromfenac Impurity 74 CAS 748735-66-2
| CAS No. | 748735-66-2 |
| Molecular Formula | C15H12BrNO3 |
| Molecular Weight | 334.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Bromfenac Impurity 74 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Bromfenac Impurity 74 (CAS 748735-66-2, C15H12BrNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bromfenac Impurity 74 (C15H12BrNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H12BrNO3 |
| Molecular Weight | 334.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac (CAS 91714-94-2)
- Bromfenac Impurity 73 (CAS CATO-C4X-200273)
- Bromfenac Impurity 10 (CAS 91714-51-1)
- Bromfenac Impurity 11 (CAS CATO-C4X-200211)
- Bromfenac Impurity 12 (CAS CATO-C4X-200212)
- Bromfenac Impurity 16 (CAS 91714-58-8)
- Bromfenac Impurity 44 (CAS CATO-C4X-200244)
- Bromfenac Impurity 55 (CAS CATO-C4X-200255)
Recommended Standards
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- 10-[4-[4,6-Di(1-adamantyl)-1,3,5-triazin-2-yl]phenyl]-10H-spiro[acridine-9,9'-fluorene](purifiedbysublimation) (CAS 2250187-16-5)
- (1,3,4-Oxadiazol-2-yl)methanol (CAS 1934983-06-8)
- 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-b]pyridine (CAS 1416712-80-5)
- 3-Methoxybenzeneacetamide (CAS 18463-71-3)
- 5-Amino-6-(methylthio)benzo[d][1,3]dioxole (CAS 68560-13-4)
- 4-bromo-1,5-dimethyl-1H-indazole (CAS 1159511-77-9)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com