O-Demethyl Vandetanib-d4 CAS 1346599-97-0
| CAS No. | 1346599-97-0 |
| Molecular Formula | - |
| Molecular Weight | 465.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including O-Demethyl Vandetanib-d4.
O-Demethyl Vandetanib-d4 (CAS 1346599-97-0), molecular formula C21H18D4BrFN4O2 and molecular weight 465.35 g/mol, is a CATO reference standard with documented purity and traceability.
O-Demethyl Vandetanib-d4 (C21H18D4BrFN4O2) contains deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures O-Demethyl Vandetanib-d4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H18D4BrFN4O2 |
| Molecular Weight | 465.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related O Standards
- N-Demethyl Vandetanib-d4 (CAS 1346603-93-7)
- 2-Demethyl Colchicine 2-O-Sulfate (CAS 1391052-56-4)
- 4-Demethyl N,N’-Bis-Boc-Trimethoprim (CAS 1346602-22-9)
- 14-demethyl-lanosterol-d6 (CAS 1246298-30-5)
- N-Demethyl Mifepristone-d3 (CAS CATO-C4X-12165)
- 6-Demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline (CAS 151922-17-7)
- 6-Demethyl 6-O-Benzyl Papaverine (CAS 18813-62-2)
- Demethyl Irbesartan (CAS 158778-58-6)
Recommended Standards
- CHIR 99021 (CAS 252917-06-9)
- 3-Bromo-4-ethoxy-N-(2-methyl-5-(6-methylbenzo[d]oxazol-2-yl)phenyl)benzamide (CAS 590397-47-0)
- 3-((3,4-Dichlorophenyl)sulfonamido)-N-(4-methoxybenzyl)benzamide (CAS 869714-27-2)
- 2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid (CAS 432001-69-9)
- 4-(tert-Butoxy)pyrimidine-5-carbaldehyde (CAS 614731-77-0)
- 4-Chlorobenzyl Alcohol (CAS 873-76-7)
- (S)-2-(2-(Trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS 1373512-28-7)
- 1,2,3-Triphenylguanidine (CAS 101-01-9)
- Sucrose dipalmitate (CAS 248917-86-4)
- tert-Butyl ((S)-1-((2-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)(2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)amino)-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate (CAS 117141-39-6)
- 2-(4-Chlorophenyl)-4-(propane-1-sulfonyl)-1h-indol-6-amine hydrochloride (CAS 1181457-71-5)
- 2,6-Dichloro-3-(trifluoromethoxy)pyridine (CAS 1221171-72-7)
- Ethyl 5-(isoquinolin-4-yl)thiophene-2-carboxylate (CAS 1187164-06-2)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com