N-Demethyl Vandetanib-d4 CAS 1346603-93-7
| CAS No. | 1346603-93-7 |
| Molecular Formula | - |
| Molecular Weight | 465.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-Demethyl Vandetanib-d4 is closely related to deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-Demethyl Vandetanib-d4 (CAS 1346603-93-7) is a high-purity analytical reference standard with the molecular formula C21H18D4BrFN4O2 and a molecular weight of 465.35 g/mol.
Structurally, N-Demethyl Vandetanib-d4 (C21H18D4BrFN4O2) contains deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 465.35 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18D4BrFN4O2 |
| Molecular Weight | 465.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- O-Demethyl Vandetanib-d4 (CAS 1346599-97-0)
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Recommended Standards
- 3-((3,4-Dichlorophenyl)sulfonamido)-N-(4-methoxybenzyl)benzamide (CAS 869714-27-2)
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- 3-Bromo-4-ethoxy-N-(2-methyl-5-(6-methylbenzo[d]oxazol-2-yl)phenyl)benzamide (CAS 590397-47-0)
- [1-(thiophene-2-sulfonyl)pyrrolidin-3-yl]methanamine hydrochloride (CAS 1420787-84-3)
- (S)-STRIP (CAS 1258276-28-6)
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- (R)-Methyl 4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoate (CAS 1391585-26-4)
- Ethyl 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carboxylate (CAS 1251017-01-2)
- 2-Methylbenzo[d]thiazole-4-carboxamide (CAS 1576881-95-2)
- Methyl 4-hydrazinyl-3-nitrobenzoate (CAS 87054-48-6)
- p-Hydroxybenzoic acid isobutyl ester sodium salt Solution in Methanol, 100μg/mL (CAS 84930-15-4)
- 4-Amino-3-bromo-5-nitrobenzaldehyde (CAS 914079-21-3)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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