Sildenafil Impurity 12 CAS 1346603-48-2
| CAS No. | 1346603-48-2 |
| Molecular Formula | C34H38N8O6S |
| Molecular Weight | 686.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Sildenafil Impurity 12 (C34H38N8O6S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 686.78 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Sildenafil Impurity 12 (CAS 1346603-48-2, C34H38N8O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sildenafil Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C34H38N8O6S |
| Molecular Weight | 686.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 1 |
Related Sildenafil Standards
- Sildenafil Impurity 307 (CAS CATO-C4X-1128307)
- Sildenafil Impurity 297 (CAS CATO-C4X-1128297)
- Sildenafil Impurity 309 (CAS CATO-C4X-1128309)
- Sildenafil Impurity 302 (CAS CATO-C4X-1128302)
- Sildenafil Impurity 87 (CAS CATO-C4X-112887)
- Sildenafil Impurity 78 (CAS CATO-C4X-112878)
- Sildenafil EP Impurity G (CAS 1346602-67-2)
- Sildenafil Impurity 268 (CAS CATO-C4X-1128268)
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