5-(3,4-Difluorophenyl)nicotinonitrile CAS 1346691-71-1
| CAS No. | 1346691-71-1 |
| Molecular Formula | C12H6F2N2 |
| Molecular Weight | 216.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-(3,4-Difluorophenyl)nicotinonitrile (C12H6F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
5-(3,4-Difluorophenyl)nicotinonitrile (CAS 1346691-71-1), molecular formula C12H6F2N2 and molecular weight 216.19 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H6F2N2 |
| Molecular Weight | 216.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorophenyl Standards
- 5-(2,3-Difluorophenyl)nicotinonitrile (CAS 1261732-07-3)
- 5-(2,4-Difluorophenyl)nicotinonitrile (CAS 1346691-68-6)
- 5-(3,5-Difluorophenyl)nicotinonitrile (CAS 1346691-77-7)
- 5-(2,6-Difluorophenyl)nicotinonitrile (CAS 1346691-82-4)
- 5-(2,5-Difluorophenyl)nicotinonitrile (CAS 1346692-24-7)
- Ethyl 2-(3,4-difluorophenyl)-2-hydroxyacetate (CAS 1248719-87-0)
- Methyl 3-(2,3-difluorophenyl)-2-hydroxypropanoate (CAS 1467976-85-7)
- Methyl 3-(2,5-difluorophenyl)-2-hydroxypropanoate (CAS 1481403-06-8)
Recommended Standards
- 5-Phenoxypyrazine-2-carboxylic acid (CAS 1342960-29-5)
- 3-Nitro-4-phenoxypyridine (CAS 132038-21-2)
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- N-(Furan-2-ylmethylene)-4-nitroaniline (CAS 13533-24-9)
- 2-Chloro-n-{5-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-yl}acetamide (CAS 304895-22-5)
- 4-Cyclopropoxybenzene-1,2-diamine (CAS 1243473-92-8)
- Tert-butyl 4-methyl-2-(2-oxo-2-phenylethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate (CAS 1899102-35-2)
- tert-Butyl N-[(E)-3-phenylprop-2-enyl]carbamate (CAS 115270-11-6)
- Cilnidipine Impurity 7 (CAS 146845-35-4)
- (R)-1-(2-Fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1079656-93-1)
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- 6-Chloro-3-cyclobutyl-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1094292-72-4)
- (3-Isopropylpyridin-4-yl)methanamine (CAS 1541815-11-5)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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