(5-(2-Chloro-5-fluorophenyl)pyridin-3-yl)methanamine CAS 1346692-32-7
| CAS No. | 1346692-32-7 |
| Molecular Formula | C12H10ClFN2 |
| Molecular Weight | 236.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (5-(2-Chloro-5-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346692-32-7), a certified reference material (molecular formula C12H10ClFN2, MW 236.67 g/mol) for analytical method development and quality control.
The molecular framework of (5-(2-Chloro-5-fluorophenyl)pyridin-3-yl)methanamine (C12H10ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClFN2 |
| Molecular Weight | 236.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- 4-Chloro-2-fluoro-1-(phenylmethoxy)benzene (CAS 1044067-73-3)
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- 4-Chloro-6-ethyl-2-(2-fluorophenyl)pyrimidine (CAS 1239845-85-2)
- (5-(4-Chloro-2-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346691-92-6)
- (5-(4-Chloro-3-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346691-97-1)
- (5-(3-Chloro-2-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346692-08-7)
Recommended Standards
- (5-(3-Chloro-5-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346692-21-4)
- 2-Chloro-2,2-difluoro-1-(3-(methylthio)phenyl)ethan-1-one (CAS 1352206-41-7)
- (5-(5-Chloro-2-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346692-15-6)
- 2-Chloro-2,2-difluoro-1-(4-(methylthio)phenyl)ethan-1-one (CAS 1352224-57-7)
- 6'-Bromo-8'-chloro-4,4-difluoro-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione (CAS 1849592-13-7)
- 3-Bromo-1-(difluoromethyl)-1H-1,2,4-triazole (CAS 2155855-86-8)
- n1-(Benzo[d]thiazol-2-yl)-n2,n2-dimethylethane-1,2-diamine (CAS 612527-76-1)
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