Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate CAS 1346809-60-6

Purity 97%+In StockPharmaceutical Standards
CAS No.1346809-60-6
Molecular FormulaC14H17F3N2O2
Molecular Weight302.29 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate CAS 1346809-60-6 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate (CAS 1346809-60-6), molecular formula C14H17F3N2O2 and molecular weight 302.29 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 302.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), Tert-butyl 6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC14H17F3N2O2
Molecular Weight302.29 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1991
Halogen ContentF-containing
Nitrogen Atoms2

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