Axitinib Impurity 1 CAS 1347304-18-0
| CAS No. | 1347304-18-0 |
| Molecular Formula | C22H18N4O2S |
| Molecular Weight | 402.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Axitinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Axitinib Impurity 1 (CAS 1347304-18-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H18N4O2S and a molecular weight of 402.47 g/mol.
The molecular framework of Axitinib Impurity 1 (C22H18N4O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H18N4O2S |
| Molecular Weight | 402.47 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Axitinib Standards
- Axitinib Impurity 27 (CAS CATO-C4X-107127)
- Axitinib Impurity 9 (CAS CATO-C4X-10719)
- Axitinib Impurity 59 (CAS CATO-C4X-107159)
- Axitinib Impurity 170 (CAS CATO-C4X-107170)
- Axitinib Impurity 79 (CAS CATO-C4X-107179)
- Axitinib Impurity 45 (CAS CATO-C4X-107145)
- Axitinib Impurity N1 (CAS 1420478-90-5)
- Axitinib Impurity 8 (CAS 885126-34-1)
Recommended Standards
- NU6102 (CAS 444722-95-6)
- N-([1,1'-Biphenyl]-2-yl)-2-((3-(2-hydroxyphenyl)-1H-1,2,4-triazol-5-yl)thio)acetamide (CAS 336180-54-2)
- Dabsyl-L-proline (CAS 89131-09-9)
- 16α,17-Epoxycorticosterone 21-Acetate (CAS 112529-49-4)
- Edoxaban Impurity 137 (CAS CATO-C4X-1063137)
- Tetracaine Impurity 26 ·xHCl (CAS CATO-C4X-192326)
- Metoclopramide impurity 63 (CAS CATO-C4X-141563)
- 2-(Quinolin-6-yl)acetic acid (CAS 5622-34-4)
- 1,3,8-Triazaspiro[4.5]Dec-1-en-4-one (CAS 885032-18-8)
- (R)-2-(1-aminoethyl)-1-phenyl-1H-benzo[d]imidazole-6-carbonitrile (CAS 1398507-87-3)
- (2-Bromoallyl)benzene (CAS 60468-22-6)
- 2-Phenyl-1-(Piperidin-1-Yl)Ethanethione (CAS 24815-46-1)
- 5-Oxo-5-(2,3,4,5-tetrafluorophenyl)pentanoic acid (CAS 951891-61-5)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com