Axitinib Impurity 45 CAS CATO-C4X-107145
| CAS No. | CATO-C4X-107145 |
| Molecular Formula | C22H20N4O2S |
| Molecular Weight | 404.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Axitinib Impurity 45 (CAS CATO-C4X-107145, C22H20N4O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Axitinib Impurity 45 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 404.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Axitinib Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H20N4O2S |
| Molecular Weight | 404.48 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Axitinib Standards
- Axitinib Impurity 1 (CAS 1347304-18-0)
- Axitinib Impurity 27 (CAS CATO-C4X-107127)
- Axitinib Impurity 9 (CAS CATO-C4X-10719)
- Axitinib Impurity 59 (CAS CATO-C4X-107159)
- Axitinib Impurity 170 (CAS CATO-C4X-107170)
- Axitinib Impurity 79 (CAS CATO-C4X-107179)
- Axitinib Impurity 8 (CAS 885126-34-1)
- Axitinib Impurity N1 (CAS 1420478-90-5)
Recommended Standards
- N-Methyl-N-(2-{4-[1-(thiophene-2-carbonyl)-1H-pyrazol-3-yl]phenoxy}ethyl)pyridin-2-amine (CAS 477713-84-1)
- Salbutamol Impurity 180 (CAS CATO-C4X-1176180)
- N,2-Dibenzyl-4-(phenylsulfonyl)oxazol-5-amine (CAS 303753-61-9)
- Relebactam Impurity 157 (CAS CATO-C4X-2144157)
- Piperidine Impurity 19 (CAS CATO-C4X-239919)
- Dimefline Impurity 2 (CAS CATO-C4X-33512)
- Formoterol impurity 143 (CAS CATO-C4X-1525143)
- (2R,5R)-5-Hydroxy-1,2-piperidinedicarboxylic acid2-methyl 1-benzylester (CAS 797801-68-4)
- N,1-Dimethyl-1H-imidazole-5-carboxamide (CAS 53525-61-4)
- 6-Fluoro-2-azaspiro[3.3]heptane hydrochloride (CAS 1423032-55-6)
- 3-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 3-(2,4-dichlorobenzoyl)- (CAS 1009716-18-0)
- 3-Fluoro-1H-indol-1-yl 4-toluenesulphonate (CAS 1035805-00-5)
- 5-(4-(tert-Butyl)phenyl)-1,3,4-oxadiazole-2(3H)-thione (CAS 306936-90-3)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com