5-(Methylsulfonyl)-2-(trifluoromethoxy)benzene-1-sulfonyl chloride CAS 1349716-91-1
| CAS No. | 1349716-91-1 |
| Molecular Formula | C8H6ClF3O5S2 |
| Molecular Weight | 338.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Methylsulfonyl)-2-(trifluoromethoxy)benzene-1-sulfonyl chloride is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-(Methylsulfonyl)-2-(trifluoromethoxy)benzene-1-sulfonyl chloride (CAS 1349716-91-1), a certified reference material (molecular formula C8H6ClF3O5S2, MW 338.71 g/mol) for analytical method development and quality control.
The molecular framework of 5-(Methylsulfonyl)-2-(trifluoromethoxy)benzene-1-sulfonyl chloride (C8H6ClF3O5S2) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O5S2 |
| Molecular Weight | 338.71 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 2 |
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Recommended Standards
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- 2,2,2-Trifluoroethyl (3-chloro-2-morpholinophenyl)carbamate (CAS 1375238-97-3)
- 4'-Fluoro-5-(trifluoromethyl)biphenyl-2-sulfonyl chloride (CAS 1214360-14-1)
- 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-phenyl-1H-pyrazol-5-amine (CAS 1823183-91-0)
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- 2-(4-Fluorophenyl)ethane-1-thiol (CAS 1055303-64-4)
- SB 3CT (CAS 292605-14-2)
- 2-Cyclopropoxy-5-nitrobenzenesulfonamide (CAS 1243408-23-2)
- 3-bromo-4-(4-methylpiperazin-1-yl)aniline hydrochloride (CAS 1803594-54-8)
- Methyl 2-isopropyl-2-methylpyrrolidine-1-carboxylate (CAS 919286-33-2)
- (2S)-1-N-Boc-5-oxo-piperidine-2-carboxylic acid (CAS 915976-41-9)
- 6-Hydroxy-2-(pyridin-3-yl)pyrimidin-4(3H)-one (CAS 204394-77-4)
- 3-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1356963-11-5)
- Semaglutide impurity 286 (CAS CATO-C4X-2226286)
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