L-Tetrahydrofolic acid CAS 135-16-0
| CAS No. | 135-16-0 |
| Molecular Formula | C19H23N7O6 |
| Molecular Weight | 445.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
L-Tetrahydrofolic acid (CAS 135-16-0), molecular formula C19H23N7O6 and molecular weight 445.43 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of L-Tetrahydrofolic acid (C19H23N7O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures L-Tetrahydrofolic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H23N7O6 |
| Molecular Weight | 445.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 7 |
Related L Standards
Recommended Standards
- Folic Acid Impurity 34 (CAS 71963-69-4)
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- 3-(4-Methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine (CAS 1268264-10-3)
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- Fexofenadine-d10 HCl (CAS 1215821-44-5)
- (E)-N-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-3-(thiophen-2-yl)acrylamide (CAS 1331448-65-7)
- 2-(2-Fluoro-5-nitro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096336-43-3)
- Biotin Impurity 37 (CAS CATO-C4X-156337)
- 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-amine (CAS 1039933-90-8)
- 4-(Naphthalen-1-yl)-3,5-diphenyl-4H-1,2,4-triazole (CAS 16152-10-6)
- (1-(3-Chlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl)methanol (CAS 618444-40-9)
- Acid Red 138 (~35% Dye Content) (CAS 15792-43-5)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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