N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrazine-2-carboxamide hydrochloride CAS 1351644-57-9
| CAS No. | 1351644-57-9 |
| Molecular Formula | C11H11N5OS |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrazine-2-carboxamide hydrochloride (CAS 1351644-57-9) is a high-purity analytical reference standard with the molecular formula C11H11N5OSHCl and a molecular weight of 297.76 g/mol.
The molecular framework of N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrazine-2-carboxamide hydrochloride (C11H11N5OSHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11N5OS HCl |
| Molecular Weight | 297.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related N Standards
- 8-Oxo-5,6,7,8-tetrahydrothiazolo[3,2-a][1,3]diazepine-3-carboxylic acid (CAS 1009571-63-4)
- 2-(5-Ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)ethan-1-amine (CAS 1016735-89-9)
- 2-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrobromide (CAS 1030122-16-7)
- n-(4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridin-2-yl)furan-2-carboxamide (CAS 1082491-76-6)
- n-(4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridin-2-yl)cyclopropanecarboxamide (CAS 1082576-96-2)
- n-(4,5,6,7-Tetrahydrothiazolo[5,4-c]pyridin-2-yl)thiophene-2-carboxamide (CAS 1082576-98-4)
- Ethyl 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (CAS 1135122-10-9)
- N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrazine-2-carboxamide (CAS 1156402-61-7)
Recommended Standards
- 6-(Perfluoroethyl)pyridine-3,4-diamine (CAS 1795359-83-9)
- Methyl (R)-2-amino-3-(pyridin-4-yl)propanoate (CAS 294887-32-4)
- 4,5-Dibromo-2-(3-chloro-4-fluorophenyl)pyridazin-3(2H)-one (CAS 221031-24-9)
- N-Ethyl-1H-1,3-benzodiazol-2-amine (CAS 21578-59-6)
- 4-(4-Pyridyl)-3-butyn-1-ol (CAS 192643-83-7)
- Micafungin Impurity 3 (CAS CATO-C4X-16953)
- 3-(pyridin-3-ylmethoxy)pyridin-2-amine (CAS 96428-82-9)
- Axitinib Impurity 58 (CAS 3037703-03-7)
- 1-Boc-3,5-dimethylpyrazole-4-boronic acid pinacol ester (CAS 1073354-70-7)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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