1-[4-chloro-3-(trifluoromethyl)phenyl]-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid CAS 1351844-81-9
| CAS No. | 1351844-81-9 |
| Molecular Formula | C12H9ClF3N3O3 |
| Molecular Weight | 335.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[4-chloro-3-(trifluoromethyl)phenyl]-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid.
CATO supplies 1-[4-chloro-3-(trifluoromethyl)phenyl]-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1351844-81-9), a certified reference material (molecular formula C12H9ClF3N3O3, MW 335.67 g/mol) for analytical method development and quality control.
1-[4-chloro-3-(trifluoromethyl)phenyl]-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid (C12H9ClF3N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[4-chloro-3-(trifluoromethyl)phenyl]-5-(methoxymethyl)-1H-1,2,3-triazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9ClF3N3O3 |
| Molecular Weight | 335.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- ethyl 1-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-1H-1,2,3,4-tetraazole-5-carboxylate (CAS 1092346-51-4)
- 1-(2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine (CAS 2096341-25-0)
- 1-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine (CAS 2096334-57-3)
- 1-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine (CAS 2096334-70-0)
- 4-Chloro-N-((perfluorophenyl)methyl)benzamide (CAS 304458-50-2)
- 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 246022-28-6)
- Ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2,2-difluoroacetate (CAS 478043-86-6)
- N-(2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)cyclopentanamine (CAS 2096341-87-4)
Recommended Standards
- 2-(3-Methylpiperidin-1-yl)-N-(2,4,6-trichlorophenyl)acetamide (CAS 332162-66-0)
- 4-Chloro-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}-5-methoxypyrimidine (CAS 339275-97-7)
- 4-Chloro-2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-5-methoxypyrimidine (CAS 338955-82-1)
- N-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)cyclopentanamine (CAS 2096337-34-5)
- 3-Propylhexan-2-amine (CAS 52030-03-2)
- Benzenaminium, 3-carboxy-4-iodyl-N,N,N-trimethyl-, inner salt(AIBX) (CAS 2643968-51-6)
- 2-((9-Methyl-9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetic acid (CAS 681838-49-3)
- 3-Ethoxy-4-[2-(4-morpholinyl)ethoxy]benzaldehyde (CAS 350998-38-8)
- H-Ile-Tyr-OH (CAS 38579-21-4)
- Methyl 4-{[2-cyano-2-(3-thienyl)vinyl]amino}benzenecarboxylate (CAS 477851-26-6)
- 1-(1-Benzyl-2,5-dioxopyrrolidin-3-yl)piperidine-4-carboxamide (CAS 895358-30-2)
- 1-Stearin-2-Olein-3-Linolein (CAS 2190-14-9)
- tert-Butyl 4-(methylsulfonyl)piperazine-1-carboxylate (CAS 164331-38-8)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
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