1-(3-Chloro-4-fluorophenyl)-2,2-difluoroethan-1-one CAS 1352223-06-3
| CAS No. | 1352223-06-3 |
| Molecular Formula | C8H4ClF3O |
| Molecular Weight | 208.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(3-Chloro-4-fluorophenyl)-2,2-difluoroethan-1-one (CAS 1352223-06-3), molecular formula C8H4ClF3O and molecular weight 208.56 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H4ClF3O, 1-(3-Chloro-4-fluorophenyl)-2,2-difluoroethan-1-one contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 208.56 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 1-(3-Chloro-4-fluorophenyl)-2,2-difluoroethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3O |
| Molecular Weight | 208.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-2-(trifluoromethyl)benzaldehyde (CAS 112641-26-6)
- 2-Chloro-1-(2,4,5-Trifluorophenyl)Ethanone (CAS 129604-31-5)
- 2-Chloro-2,2-difluoro-1-(4-fluorophenyl)ethan-1-one (CAS 1321028-35-6)
- 1-(3-Chloro-5-fluorophenyl)-2,2-difluoroethan-1-one (CAS 1352208-84-4)
- 1-(4-Chloro-3-fluorophenyl)-2,2-difluoroethan-1-one (CAS 1352217-65-2)
- 2-Chloro-2,2-difluoro-1-(3-fluorophenyl)ethan-1-one (CAS 1352222-12-8)
- 2’-Chloro-2,2,2-trifluoroacetophenone (CAS 5860-95-7)
- 2-Chloro-1-(2,4,6-trifluorophenyl)ethanone (CAS 223785-96-4)
Recommended Standards
- 2-(Trifluoromethyl)benzoyl Chloride (CAS 312-94-7)
- 2,4,6-Trifluoro-benzeneacetyl ChlorideDISCONTINUED, offer stable T793535 (CAS 714963-55-0)
- 2-Chloro-1-(2,4-difluorophenyl)-2-fluoroethanone (CAS 94119-78-5)
- 3,4,6-Trifluoro-2-methylbenzoyl Chloride (CAS 119915-41-2)
- 3-(bromomethyl)-2-chloro-1-benzofuran (CAS 2031260-78-1)
- N-(1,1,1-trifluoropropan-2-yl)thietan-3-amine (CAS 1872744-80-3)
- 1-(4-Butylphenyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine (CAS 1416339-54-2)
- N-methyl-1H-imidazole-5-carboxamide (CAS 53525-55-6)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (CAS 1176723-60-6)
- 2-Hydrazinyl-4-(1-methyl-1h-pyrazol-3-yl)pyrimidine (CAS 1006322-90-2)
- 5-AIQ (hydrochloride) (CAS 93117-07-8)
- 2-(Piperazin-1-yl)phenol (CAS 1011-17-2)
- 2-Amino-2-(3,4-difluorophenyl)propanoic acid (CAS 1152858-59-7)
- Tirzepatide Impurity 34 (CAS CATO-C4X-324034)
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