5-(Difluoromethoxy)-3-iodo-1H-indazole CAS 1352395-59-5

Purity 97%+In StockPharmaceutical Standards
CAS No.1352395-59-5
Molecular FormulaC8H5F2IN2O
Molecular Weight310.04 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

5-(Difluoromethoxy)-3-iodo-1H-indazole CAS 1352395-59-5 chemical structure

Description

The occurrence of 5-(Difluoromethoxy)-3-iodo-1H-indazole is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

5-(Difluoromethoxy)-3-iodo-1H-indazole (CAS 1352395-59-5) is a high-purity analytical reference standard with the molecular formula C8H5F2IN2O and a molecular weight of 310.04 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, 5-(Difluoromethoxy)-3-iodo-1H-indazole is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 310.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 5-(Difluoromethoxy)-3-iodo-1H-indazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H5F2IN2O
Molecular Weight310.04 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1991
Halogen ContentF/I-containing
Nitrogen Atoms2

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