(2E)-1-(4-chloro-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one CAS 135251-11-5
| CAS No. | 135251-11-5 |
| Molecular Formula | C11H12ClNO2 |
| Molecular Weight | 225.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(2E)-1-(4-chloro-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one (CAS 135251-11-5), molecular formula C11H12ClNO2 and molecular weight 225.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2E)-1-(4-chloro-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one (C11H12ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H12ClNO2 |
| Molecular Weight | 225.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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- 6-Fluoro-8-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 1780395-39-2)
- Boc-Pro-ONp (CAS 28310-65-8)
- Fusidate Sodium (CAS 751-94-0)
- 3-(4-(1H-pyrazol-1-yl)phenyl)acrylic acid (CAS 1006441-28-6)
- 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)ethan-1-amine (CAS 1292180-21-2)
- 3-(N,N-Dimethylamino)phenylboronic acid hydrochloride (CAS 1256355-23-3)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
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