5-chloro-3-(trifluoromethyl)-1,6-naphthyridine CAS 1352935-05-7
| CAS No. | 1352935-05-7 |
| Molecular Formula | C9H14ClF3N2 |
| Molecular Weight | 242.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
5-chloro-3-(trifluoromethyl)-1,6-naphthyridine (CAS 1352935-05-7) is a high-purity analytical reference standard with the molecular formula C9H14ClF3N2 and a molecular weight of 242.67 g/mol.
The molecular framework of 5-chloro-3-(trifluoromethyl)-1,6-naphthyridine (C9H14ClF3N2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14ClF3N2 |
| Molecular Weight | 242.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 3-Trifluoromethylsulfanyl-propane-1-sulfonyl chloride (CAS 1422766-26-4)
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- Tert-butyl 3-(((3-iodopyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate (CAS 1171920-04-9)
- 2-Chloro-3-methoxybenzenesulfonamide (CAS 1261642-41-4)
- ((2R,3S,5R)-5-(2-(Ethylamino)-6-oxo-3H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 138328-54-8)
- 2-Nitrothiazole-5-carboxylic acid (CAS 59521-24-3)
- Coelenterazine ch (CAS 123437-26-3)
- a-Bromoheptanoic acid (CAS 2624-01-3)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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