N-(2-Chloro-3-methoxybenzyl)-2,2-dimethylpropanamide CAS 1354357-95-1
| CAS No. | 1354357-95-1 |
| Molecular Formula | C13H18ClNO2 |
| Molecular Weight | 255.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(2-Chloro-3-methoxybenzyl)-2,2-dimethylpropanamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-(2-Chloro-3-methoxybenzyl)-2,2-dimethylpropanamide (CAS 1354357-95-1) is a high-purity analytical reference standard with the molecular formula C13H18ClNO2 and a molecular weight of 255.74 g/mol.
The molecular framework of N-(2-Chloro-3-methoxybenzyl)-2,2-dimethylpropanamide (C13H18ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), N-(2-Chloro-3-methoxybenzyl)-2,2-dimethylpropanamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18ClNO2 |
| Molecular Weight | 255.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- (S)-2-Amino-N-((6-chloropyridin-3-yl)methyl)-N,3-dimethylbutanamide (CAS 1354016-58-2)
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- (S)-2-Amino-N-((6-chloropyridin-3-yl)methyl)-N-isopropylpropanamide (CAS 1354008-88-0)
- Ethyl 4-((4-chlorobenzyl)amino)butanoate (CAS 1391078-34-4)
- 4-Amino-3-(difluoromethyl)-6-methoxypyridine-2-sulfonamide (CAS 1804681-85-3)
- {[2-(3-Methoxyphenyl)-1,3-thiazol-5-yl]-methyl}amine dihydrochloride (CAS 1185709-34-5)
- 8-Fluoro-2,6-dimethylquinoline (CAS 1420790-21-1)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 98968-77-5)
- N1-Cyclohexyl-N2-(2-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl)oxalamide (CAS 946281-16-9)
- 2-Chloro-N-methyl-N-((3-(methylthio)pyrazin-2-yl)methyl)acetamide (CAS 1353961-12-2)
- N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide (CAS 423181-33-3)
- 2-(Methyl(pyrazin-2-yl)amino)ethan-1-ol (CAS 866156-88-9)
- 5-(Aminomethyl)-N-benzyl-N,6-dimethylpyridin-2-amine (CAS 1355232-72-2)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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