N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide CAS 423181-33-3
| CAS No. | 423181-33-3 |
| Molecular Formula | C13H10ClN3O2 |
| Molecular Weight | 275.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide.
N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide (CAS 423181-33-3), molecular formula C13H10ClN3O2 and molecular weight 275.69 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide (C13H10ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), N-(4-Chloro-3-cyano-7-methoxyquinolin-6-yl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10ClN3O2 |
| Molecular Weight | 275.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- N-(3-Chloro-phenyl)-phthalamic acid (CAS 5406-21-3)
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- N-(2-Carbamoyl-phenyl)-2-chloro-nicotinamide (CAS 535977-08-3)
- N-(4-Chloro-phenyl)-phthalamic acid (CAS 7142-94-1)
- tert-Butyl 3-(pyridin-3-yl)propanoate (CAS 1107665-45-1)
- 2-(1H-Benzoimidazol-2-yl)-N-(2-methoxy-ethyl)-acetamide (CAS 519152-81-9)
- N-((Methylcarbamoyl)oxy)-2-(quinolin-8-yloxy)acetimidamide (CAS 88758-91-2)
- Sofosbuvir Impurity 51 (CAS 1233335-78-8)
- 4-[3-(Aminomethyl)-2-pyridinyl]-2-piperazinone (CAS 953894-31-0)
- AM 404-d4 (CAS 1185244-71-6)
- 4,6-Dichloro-2-(o-tolyl)pyrimidine (CAS 26863-54-7)
- 6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1779766-69-6)
- 1,12-Bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecanedibromide (CAS 321915-72-4)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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