4-(4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-ureido)-3-fluorophenoxy)-N-methylpicolinamide CAS 1354650-00-2
| CAS No. | 1354650-00-2 |
| Molecular Formula | C22H25FN6O3 |
| Molecular Weight | 440.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 440.47 g/mol gives 4-(4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-ureido)-3-fluorophenoxy)-N-methylpicolinamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-(4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-ureido)-3-fluorophenoxy)-N-methylpicolinamide (CAS 1354650-00-2), molecular formula C22H25FN6O3 and molecular weight 440.47 g/mol, is a CATO reference standard with documented purity and traceability.
4-(4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-ureido)-3-fluorophenoxy)-N-methylpicolinamide (C22H25FN6O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25FN6O3 |
| Molecular Weight | 440.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Recommended Standards
- 2-(6-Phenyl-3-(3,4,5-trimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid (CAS 126598-10-5)
- 1-(2,5-Dimethoxyphenyl)-2-(triphenylphosphoranylidene)ethanone (CAS 141957-50-8)
- Etrasimod Impurity 49 (CAS 1788895-59-9)
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- Thiazole-5-thiol (CAS 120405-09-6)
- 2-(Hydrazinecarbonyl)benzenesulfonamide (CAS 102169-52-8)
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