7-Amino-2-(4-methoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one CAS 1354764-86-5
| CAS No. | 1354764-86-5 |
| Molecular Formula | C12H11N5O2 |
| Molecular Weight | 257.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Amino-2-(4-methoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one.
7-Amino-2-(4-methoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one (CAS 1354764-86-5) is a high-purity analytical reference standard with the molecular formula C12H11N5O2 and a molecular weight of 257.25 g/mol.
The molecular framework of 7-Amino-2-(4-methoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one (C12H11N5O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Amino-2-(4-methoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11N5O2 |
| Molecular Weight | 257.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Amino Standards
- 4-Amino-7-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (CAS 115044-83-2)
- 2-[5-Amino-3-(furan-2-yl)-1H-pyrazol-1-yl]-6-methyl-3,4-dihydropyrimidin-4-one (CAS 1416340-51-6)
- 5-Amino-1-(3-methoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1416342-15-8)
- 5-Amino-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 1416345-16-8)
- 2-(2-(5-Amino-1H-1,2,4-triazol-3-yl)ethyl)isoindoline-1,3-dione (CAS 313499-41-1)
- 3-Amino-5-(4-methoxyphenyl)-1H,5H,6H-pyrazolo[4,3-c]pyridazin-6-one (CAS 338395-98-5)
- 4-amino-1,3-dimethyl-pyrazolo[4,3-c][1,7]naphthyridine-8-carboxylic acid (CAS 2774613-92-0)
- 4-amino-1,7-dimethyl-pyrazolo[4,3-c][1,8]naphthyridine-8-carboxylic acid (CAS 2790570-00-0)
Recommended Standards
- 1-Methyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (CAS 1354706-49-2)
- N-(3-(trifluoromethyl)phenyl)cyclopentanecarboxamide (CAS 13691-84-4)
- 1-Methyl-4-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[3,4-b]pyridine-3-carboxylic acid (CAS 1354704-42-9)
- 2-((3-(Hydroxymethyl)phenyl)amino)-1H-purin-6(9H)-one (CAS 123994-71-8)
- Choline Chloride (CAS 67-48-1)
- Ethyl 3-(methyl(phenyl)amino)propanoate (CAS 2003-76-1)
- 2-Methoxy-5-(4-nitrophenyl)-1,3,4-oxadiazole (CAS 102925-87-1)
- (2Z)-2-[(2,4-Dichlorophenyl)methylidene]-1-azabicyclo[2.2.2]octan-3-one (CAS 53898-72-9)
- 2-Chloro-3-methyl-5-(trifluoromethyl)pyridine (CAS 223549-97-1)
- Dutasteride Impurity 20 (CAS 3822-20-6)
- 3,3,4,4-Tetrafluorobenzophenone (CAS 117320-03-3)
- 5-Oxo-5-((4-sulfamoylphenyl)amino)pentanoic acid (CAS 99842-19-0)
- 3-(5-Ethyl-1,2,4-oxadiazol-3-yl)morpholine (CAS 1565329-30-7)
- Semaglutide Impurity 158 (x TFA Salt) (CAS CATO-C4X-2226158)
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