tert-Butyl 5-chloro-2,4-difluorobenzoate CAS 1354961-13-9
| CAS No. | 1354961-13-9 |
| Molecular Formula | C11H11ClF2O2 |
| Molecular Weight | 248.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 5-chloro-2,4-difluorobenzoate (CAS 1354961-13-9), molecular formula C11H11ClF2O2 and molecular weight 248.65 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, tert-Butyl 5-chloro-2,4-difluorobenzoate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 248.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), tert-Butyl 5-chloro-2,4-difluorobenzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11ClF2O2 |
| Molecular Weight | 248.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Recommended Standards
- Ethyl 2-(3-chloro-2-methylphenyl)-2,2-difluoroacetate (CAS 1215205-45-0)
- 4-Butoxy-2,6-difluorobenzoyl chloride (CAS 1373920-74-1)
- 3940AF 7-Methoxy-2,1,3-benzoxadiazole-4-sulfonyl chloride 944780-94-3 C7H5ClN2O4S (CAS 944780-94-3)
- 2-Butoxy-3,5-difluorobenzoyl chloride (CAS 1443309-93-0)
- Ethyl 2-amino-5-(trifluoromethyl)-2,3-dihydro-1H-indene-2-carboxylate hydrochloride (CAS 1272758-27-6)
- tert-Butyl (5-methoxypiperidin-3-yl)carbamate (CAS 1822590-63-5)
- 3-Chlorophenyl (2E)-3-(6-bromo-2H-1,3-benzodioxol-5-yl)prop-2-enoate (CAS 478259-32-4)
- N-Cyclopropyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxamide (CAS 1707563-10-7)
- 1-(2-Bromo-6-nitrophenyl)ethanamine (CAS 1391310-80-7)
- 2-Chloro-n-(3-cyano-4,5-dimethylfuran-2-yl)acetamide (CAS 72965-47-0)
- Methyl 2-((2-methyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-6-yl)thio)acetate (CAS 1018166-65-8)
- 2-(Pyridin-3-yl)tetrahydro-2H-thiopyran-2-carboxamide (CAS 1352522-89-4)
- 3-(tert-Butyl)-1-(isoquinolin-6-yl)-1H-pyrazol-5-amine (CAS 1951451-76-5)
- Des-Ile12-Aib13-Tirzepatide (CAS CATO-CPTD788960)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com