Methyl 6-(difluoromethyl)nicotinate CAS 1355729-43-9
| CAS No. | 1355729-43-9 |
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 6-(difluoromethyl)nicotinate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl 6-(difluoromethyl)nicotinate (CAS 1355729-43-9) is a high-purity analytical reference standard with the molecular formula C8H7F2NO2 and a molecular weight of 187.14 g/mol.
Structurally, Methyl 6-(difluoromethyl)nicotinate (C8H7F2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 187.14 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 6-(difluoromethyl)nicotinate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H7F2NO2 |
| Molecular Weight | 187.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 2-(Difluoromethyl)-3-methylpyridine-5-carboxylic acid (CAS 1105976-40-6)
- 2-(Difluoromethyl)-4-methylpyridine-5-carboxylic acid (CAS 1105995-37-6)
- 2-(Difluoromethyl)pyridine-5-acetic acid (CAS 1211540-34-9)
- 2-[5-(Difluoromethyl)pyridin-2-yl]acetic acid (CAS 1211587-21-1)
- Methyl 2-(difluoromethyl)isonicotinate (CAS 1251844-44-6)
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- 2-(Difluoromethyl)-5-nitrotoluene (CAS 1261605-89-3)
Recommended Standards
- Methyl 2,2-difluoro-2-(pyridin-3-yl)acetate (CAS 1354940-86-5)
- Methyl 2-(difluoromethyl)nicotinate (CAS 1355729-93-9)
- (2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methanamine (CAS 135132-35-3)
- Methyl 4-(difluoromethyl)nicotinate (CAS 1355730-00-5)
- 1-Methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (CAS 294646-72-3)
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- Tert-butyl ((1S,2R)-2-phenylcyclopropyl)carbamate (CAS 185256-49-9)
- (1-(Piperidin-1-yl)cyclohexyl)methanamine (CAS 41805-36-1)
- 2-oxo-6-(propan-2-yl)-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (CAS 1267469-16-8)
- 6-Nitro-1,2,3,4-tetrahydroquinoxaline (CAS 41959-35-7)
- (((((((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)methyl)phosphonic acid (CAS 3469-78-1)
- 1-(4-Butoxy-phenyl)-2-(1,3-dioxolan-2-yl)-ethanone (CAS 1263365-69-0)
- Dimethyl butylphosphonate (CAS 24475-23-8)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
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