2-Chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile CAS 13600-48-1
| CAS No. | 13600-48-1 |
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile (C8H4ClF3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile (CAS 13600-48-1) is a high-purity analytical reference standard with the molecular formula C8H4ClF3N2 and a molecular weight of 220.58 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-6-(trifluoromethyl)-1H-indazole (CAS 1000341-24-1)
- 4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1014613-16-1)
- 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 1019027-76-9)
- 5-Chloro-2-(trifluoromethyl)benzofuran (CAS 1067238-68-9)
- 2-Chloro-7-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1075753-27-3)
- 2-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 112601-16-8)
- 3-Chloro-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine (CAS 1190312-01-6)
- 3-Chloro-6-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine (CAS 1190319-49-3)
Recommended Standards
- 4-Chloro-6-(trifluoromethyl)-1H-indazole (CAS 1352398-67-4)
- 7-Chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1360899-39-3)
- 2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (CAS 133013-29-3)
- 5-Chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1360940-71-1)
- 2-(trifluoromethyl)furan-3-carbaldehyde (CAS 1378259-70-1)
- 4-Amino-5-fluoro-2-(trifluoromethyl)benzonitrile (CAS 1398046-66-6)
- 2-(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile (CAS 4414-86-2)
- Levosimendan Impurity 59 (CAS CATO-C4X-130859)
- Piperazine Impurity 15 (CAS 10430-90-7)
- Gadobutrol Impurity 17 (CAS 127723-03-9)
- N-(3-bromo-4-methylphenyl)tetrahydrothiophen-3-amine (CAS 1341906-38-4)
- 1-(4-Chlorobenzoyl)-5-oxo-N,N-dipropylpyrrolidine-2-carboxamide (CAS 85760-87-8)
- 5-Bromo-7-methyl-2,3-dihydro-1H-inden-4-ol (CAS 175136-06-8)
- [Plus-β-Ala28]-Semaglutide (CAS CATO-C4X-2226221)
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