2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile CAS 133013-29-3
| CAS No. | 133013-29-3 |
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (C8H4ClF3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (CAS 133013-29-3), a certified reference material (molecular formula C8H4ClF3N2, MW 220.58 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Amino-3-chloro-5-(trifluoromethyl)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3N2 |
| Molecular Weight | 220.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-4-chloro-5-(trifluoromethyl)benzonitrile (CAS 1217302-11-8)
- 5-Amino-4-chloro-2-(trifluoromethyl)benzonitrile (CAS 1805524-35-9)
- 2-Amino-5-chloro-3-(trifluoromethyl)benzonitrile (CAS 74396-76-2)
- 4-Amino-3-chloro-5-(trifluoromethyl)benzonitrile (CAS 62584-25-2)
- 4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile (CAS 888073-09-4)
- 2-Amino-5-(chloromethyl)-4-(difluoromethyl)nicotinaldehyde (CAS 1805333-65-6)
- 2-Amino-6-(chloromethyl)-4-(difluoromethyl)nicotinaldehyde (CAS 1805333-76-9)
- 4-Amino-6-(difluoromethyl)-5-methylpicolinoyl chloride (CAS 1805361-73-2)
Recommended Standards
- 3-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1289197-40-5)
- 4-Chloro-6-(trifluoromethyl)-1H-indazole (CAS 1352398-67-4)
- 5-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1256809-31-0)
- 2-Chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile (CAS 13600-48-1)
- 7-(2-Methoxyphenyl)-7-oxoheptanenitrile (CAS 898786-54-4)
- 2-(4-Fluorophenyl)acetaldehyde (CAS 1736-67-0)
- Methyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)benzoate (CAS 852952-21-7)
- 6-(3-hydroxy-3-thiazol-2-yl-but-1-ynyl)-1,2-benzoxazol-3-one (CAS 2475482-28-9)
- 3-((3-Methoxyphenyl)amino)-2,3-dihydrothiophene 1,1-dioxide (CAS 39565-74-7)
- Boc-NH-PPG2 (CAS 1312905-31-9)
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- 3-Methoxypyridin-2-amine hydrochloride (CAS 1951439-54-5)
- Des-Asp15-Tirzepatide (CAS CATO-CPTD788958)
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