(3R,4S)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid CAS 1363594-80-2
| CAS No. | 1363594-80-2 |
| Molecular Formula | C12H12F3NO2 |
| Molecular Weight | 259.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3R,4S)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(3R,4S)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid (CAS 1363594-80-2), molecular formula C12H12F3NO2 and molecular weight 259.22 g/mol, is a CATO reference standard with documented purity and traceability.
(3R,4S)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid (C12H12F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (3R,4S)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12F3NO2 |
| Molecular Weight | 259.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 2-(8-(3-Methyl-1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)acetic acid (CAS 1355236-24-6)
- (R)-2-(pyrrolidin-2-yl)-3-(trifluoromethyl)benzoic acid (CAS 1388712-31-9)
- 2-(6-(3-Methyl-1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)acetic acid (CAS 1355175-26-6)
- (R)-4-(pyrrolidin-2-yl)-2-(trifluoromethyl)benzoic acid (CAS 1388804-52-1)
- 2-Chloro-n-(3-cyclopropyl-1-phenyl-1h-pyrazol-5-yl)acetamide (CAS 649701-41-7)
- 4-(1-Chloropropan-2-yl)morpholine (CAS 76191-26-9)
- 2-(3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl)ethan-1-amine dihydrochloride (CAS 1376393-91-7)
- 6-(Difluoromethyl)quinoline (CAS 1416806-01-3)
- Diphenylalanine (CAS 62653-26-3)
- Isopropyl 3-Mercaptopropionate (CAS 7383-64-4)
- 4-Amino-5-bromo-1H-pyrrolo[2,3-d]pyrimidine (CAS 22276-99-9)
- 4-(1H-Benzo[d]imidazol-2-yl)-N-(thiophen-2-yl)piperidine-1-carboxamide (CAS 1203194-42-6)
- methyl thieno[3,2-b]pyridine-2-carboxylate (CAS 478149-02-9)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com