Imatinib bis Impurity CAS 1365802-18-1
| CAS No. | 1365802-18-1 |
| Molecular Formula | C52H48N12O2 |
| Molecular Weight | 873.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Imatinib bis Impurity (CAS 1365802-18-1, C52H48N12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C52H48N12O2, Imatinib bis Impurity contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 873.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C52H48N12O2 |
| Molecular Weight | 873.02 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 35.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 12 |
Related Imatinib Standards
- Imatinib Impurity 43 (CAS CATO-C4X-106843)
- Imatinib EP Impurity D (CAS 1821122-73-9)
- Imatinib Impurity 9 (CAS CATO-C4X-10689)
- Imatinib Impurity 22 (CAS 1356565-46-2)
- Imatinib Impurity 40 (CAS CATO-C4X-106840)
- Imatinib Impurity 11 (CAS CATO-C4X-106811)
- Imatinib Impurity 41 (CAS CATO-C4X-106841)
- Imatinib Impurity 92 (CAS CATO-C4X-106892)
Recommended Standards
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Why CATO?
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