Rupatadine impurity 48 CAS 156611-76-6
| CAS No. | 156611-76-6 |
| Molecular Formula | C26H26ClN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Rupatadine impurity 48 (C26H26ClN3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Rupatadine impurity 48 (CAS 156611-76-6, C26H26ClN3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Rupatadine impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H26ClN3 3*HCl |
| Molecular Weight | 452.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Rupatadine Standards
- Rupatadine Impurity 21 (CAS 1007089-84-0)
- Rupatadine Impurity 24 (CAS 100910-66-5)
- Rupatadine Impurity 3 (CAS 102074-19-1)
- Rupatadine impurity 1 (CAS 1118754-56-5)
- Rupatadine impurity 14 (CAS 1210824-61-5)
- Rupatadine EP Impurity C (CAS 1224515-72-3)
- Rupatadine Impurity 4 (CAS 1235342-53-6)
- Rupatadine EP Impurity A (CAS 1354055-68-7)
Recommended Standards
- Entacapone EP Impurity I (CAS 1364322-42-8)
- Propafenone Impurity 10 (CAS 86383-32-6)
- Tenofovir Alafenamide 64 (CAS CATO-C4X-179764)
- 2,6-Diphenyl-2H-thiopyran-4(3H)-one (CAS 60839-95-4)
- 3,5,6-Trichloro-N,N-diethylpyridazin-4-amine (CAS 67370-21-2)
- Butanoic acid, 2-ethyl-, 1,1'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)] ester (CAS 95-08-9)
- 2'-Deoxy-5'-O-DMT-N (CAS 127062-22-0)
- 1-(1-methyl-1H-1,2,3-triazol-4-yl)ethan-1-one (CAS 128979-26-0)
- 2,6-Difluoro-N,N-dimethylbenzamide (CAS 81652-57-5)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com