4-(Difluoromethoxy)benzofuran-6-carboxylic acid CAS 1365962-35-1
| CAS No. | 1365962-35-1 |
| Molecular Formula | C10H6F2O4 |
| Molecular Weight | 228.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Difluoromethoxy)benzofuran-6-carboxylic acid (C10H6F2O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-(Difluoromethoxy)benzofuran-6-carboxylic acid (CAS 1365962-35-1), molecular formula C10H6F2O4 and molecular weight 228.15 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Difluoromethoxy)benzofuran-6-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6F2O4 |
| Molecular Weight | 228.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 3-(Difluoromethoxy)benzofuran-2-carboxylic acid (CAS 1708401-47-1)
- 6-(difluoromethoxy)-1-benzofuran-2-carboxylic acid (CAS 1803591-71-0)
- 5-(Difluoromethoxy)-1H-indazole-3-carboxylic acid (CAS 858661-78-6)
- 6-(Difluoromethoxy)-1H-indazole-3-carboxylic acid (CAS 858661-80-0)
- 3-[2-(difluoromethoxy)phenyl]but-2-enoic acid (CAS 1049158-10-2)
- 2-[2-(difluoromethoxy)phenyl]cyclopropane-1-carboxylic acid (CAS 1157139-29-1)
- 2-(4-(Difluoromethoxy)phenyl)cyclopropane-1-carboxylic acid (CAS 1157554-33-0)
- 2-(Difluoromethoxy)-5-formylphenylpropanal (CAS 1805863-02-8)
Recommended Standards
- 2',3',5',6'-Tetrafluoro-3,4'-bipyridine (CAS 1214384-47-0)
- 2,3,5,6-Tetrafluoro-4,4'-bipyridine (CAS 1214363-77-5)
- Pyridazin-3-yl trifluoromethanesulfonate (CAS 1031928-95-6)
- 4-Cyano-2-(difluoromethyl)-5-methoxynicotinic acid (CAS 1804730-59-3)
- 5-Nitropentyl Acetate (CAS 21461-51-8)
- Ethyl 2-(4-bromothiophen-3-yl)-2-oxoacetate (CAS 704200-66-8)
- n-{2-[(4-fluorophenyl)sulfanyl]ethyl}aniline (CAS 1275711-70-0)
- 1,3-Benzenedicarboxylic acid, polymer with 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, nonanoate (CAS 68987-26-8)
- Norepinephrine Impurity 57 (CAS 29477-54-1)
- 4-Bromo-n-ethylaniline (CAS 68254-64-8)
- 2-Methoxy-4-ethylphenol (CAS 2785-89-9)
- 5’-Fluoro-2-hydroxy-2’-methoxyacetophenone (CAS 1247813-37-1)
- 5-(4-Fluoro-2-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrazin-2-amine (CAS 1956356-02-7)
- (Ser(PO?H?)3??·???)-Tau Peptide (379-408) trifluoroacetate salt (CAS 2022956-60-9)
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