1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS 136675-88-2
| CAS No. | 136675-88-2 |
| Molecular Formula | C9H11FN2O4 |
| Molecular Weight | 230.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 136675-88-2) is a high-purity analytical reference standard with the molecular formula C9H11FN2O4 and a molecular weight of 230.19 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 230.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H11FN2O4 |
| Molecular Weight | 230.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- (S)-3-Amino-3-methyl-6-(trifluoromethyl)indolin-2-one (CAS 1344477-85-5)
- 1-(4-Amino-2,3-dihydro-1h-indol-1-yl)-2,2,2-trifluoroethan-1-one (CAS 1368864-43-0)
- 3-(1H-1,3-Benzodiazol-1-yl)-1,1,1-trifluoropropan-2-ol (CAS 1340095-62-6)
- 1-[3-(trifluoromethyl)phenyl]imidazolidin-2-one (CAS 14088-95-0)
- (Z)-2-Methyl-4-((5-nitrothiophen-2-yl)methylene)oxazol-5(4H)-one (CAS 89035-34-7)
- 10-Hydroxyacridine-9(10H)-thione (CAS 177793-33-8)
- 2-Amino-2-(trifluoromethyl)hex-5-enoic acid (CAS 887267-88-1)
- 2,6-Diamino-5-phenylpyrimidin-4(1H)-one (CAS 3415-83-6)
- 2-Nitro-5-(piperazin-1-yl)-N-((tetrahydrofuran-2-yl)methyl)aniline (CAS 524033-98-5)
- Thiamine Impurity 32 (CAS 52164-53-1)
- Itopride Impurity 18 (CAS 24197-95-3(Free Base))
- (3Z)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-[(dimethylamino)methylidene]-2,3-dihydro-1H-indol-2-one (CAS 400081-30-3)
- 6,7-difluoro-3,4-dihydro-2H-1$l^{6}-benzothiopyran-1,1,4-trione (CAS 1094476-70-6)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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