Lubiprostone impurity 8 CAS 136790-79-9
| CAS No. | 136790-79-9 |
| Molecular Formula | C26H34F2O5 |
| Molecular Weight | 464.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Lubiprostone impurity 8 (C26H34F2O5) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 464.54 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lubiprostone impurity 8 (CAS 136790-79-9, C26H34F2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H34F2O5 |
| Molecular Weight | 464.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
Related Lubiprostone Standards
- Lubiprostone Impurity 14 (CAS CATO-C4X-113614)
- Lubiprostone impurity 5 (CAS CATO-C4X-11365)
- Lubiprostone Impurity 21 (CAS CATO-C4X-113621)
- Lubiprostone Impurity 28 (CAS CATO-C4X-113628)
- Lubiprostone Impurity 12 (CAS 1447733-80-3)
- Lubiprostone impurity 6 (CAS 945651-35-4)
- Lubiprostone Impurity 23 (CAS CATO-C4X-113623)
- Lubiprostone-d9 (CAS 1134188-25-2)
Recommended Standards
- Ibrutinib Impurity 172 (CAS CATO-C4X-1064172)
- Flupentixol Impurity 16 (CAS CATO-C4X-189516)
- N-(2-(4-(1-((4-methoxyphenyl)sulfonyl)-1H-pyrazol-3-yl)phenoxy)ethyl)-N-methylpyridin-2-amine (CAS 477713-82-9)
- Flumetasone Impurity 7 (CAS 61633-73-6)
- Capmatinib Impurity 5 (CAS 1029714-88-2)
- Esmolol Impurity 46 (CAS 112805-66-0)
- Risperidone Impurity 37 (CAS CATO-C4X-111137)
- 4-(3,4-Dimethoxyphenyl)benzo[b]thiophene-6-carboxylic acid (CAS 1225745-31-2)
- 5-Methoxy-2-nitrophenylboronic acid (CAS 860033-98-3)
- 2-((3-Cyano-4-(3,4-dimethoxyphenyl)-6-(p-tolyl)pyridin-2-yl)thio)-N-(4-methyl-3-nitrophenyl)propanamide (CAS 332100-62-6)
- 6-(Hydroxymethyl)tetrahydro-2H-pyran-2-one (CAS 81683-96-7)
- 2-((4-Allyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(naphthalen-1-yl)acetamide (CAS 578004-41-8)
- 3-(4-(Pentyloxy)benzoyl)phenyl acetate (CAS 890100-06-8)
- [D-Ser6]-Semaglutide (CAS CATO-C4X-2226287)
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