5-(Pyridin-3-yl)-1H-1,2,3-triazole-4-carboxylic acid CAS 1368022-31-4
| CAS No. | 1368022-31-4 |
| Molecular Formula | C8H6N4O2 |
| Molecular Weight | 190.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(Pyridin-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1368022-31-4) is a high-purity analytical reference standard with the molecular formula C8H6N4O2 and a molecular weight of 190.16 g/mol.
The molecular framework of 5-(Pyridin-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (C8H6N4O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6N4O2 |
| Molecular Weight | 190.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 4 |
Related Pyridin Standards
- 2-(Pyridin-2-yl)-1,3-oxazole-4-carboxylic acid (CAS 1014630-44-4)
- 2-(pyridin-3-yl)-1,3-oxazole-4-carboxylic acid (CAS 1014630-48-8)
- 5-(Pyridin-3-yl)oxazole-4-carboxylic acid (CAS 1083224-10-5)
- 6-(Pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione (CAS 116670-76-9)
- 5-(Pyridin-4-yl)oxazole-4-carboxylic acid (CAS 118040-25-8)
- 3-(Pyridin-2-yl)-3H-1,2,4-triazole-5-carboxylic acid (CAS 1486465-50-2)
- 5-(Pyridin-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1503153-88-5)
- 5-(Pyridin-2-yl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1517060-17-1)
Recommended Standards
- 6-Formylimidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1359655-86-9)
- 3-Formylimidazo[1,2-a]pyridine-8-carboxylic acid (CAS 1368083-07-1)
- 5-oxo-5,6-dihydro-1,6-naphthyridine-2-carboxylic acid (CAS 1354555-25-1)
- 5-formylpyrazolo[1,5-a]pyridine-3-carboxylic acid (CAS 1368168-29-9)
- Velpatasvir Impurity 10 (CAS CATO-C4X-289410)
- 1-(Benzo[d][1,3]dioxol-5-yl)-3-((3-chloro-4-methylphenyl)amino)propan-1-one (CAS 477334-02-4)
- D-α-Tocopherol Succinate (CAS 4345-03-3)
- 4,5-Dichloro-3-(difluoromethoxy)thiophene-2-carboxylic acid (CAS 1779124-11-6)
- N,N-Dimethyl-2-(2-phenoxyethoxy)ethanamine (CAS 100252-25-3)
- N-Phenyl-4-(thiophen-2-yl)benzamide (CAS 338794-37-9)
- tert-Butyl (5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate (CAS 1310404-52-4)
- 3-Chloro-4-(chloromethyl)pyridin-2-ol (CAS 1227607-01-3)
- 6-(Azepan-1-yl)hexan-1-amine (CAS 21920-79-6)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
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