4-Amino-5-chlorothiophene-2-carbonitrile CAS 1369166-92-6
| CAS No. | 1369166-92-6 |
| Molecular Formula | C5H3ClN2S |
| Molecular Weight | 158.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Amino-5-chlorothiophene-2-carbonitrile (CAS 1369166-92-6) is a high-purity analytical reference standard with the molecular formula C5H3ClN2S and a molecular weight of 158.61 g/mol.
Based on its molecular formula C5H3ClN2S, 4-Amino-5-chlorothiophene-2-carbonitrile contains a nitrile group, sulfur-containing functionality, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 158.61 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3ClN2S |
| Molecular Weight | 158.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Amino Standards
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- 38487-86-4 2-Amino-4-chlorobenzonitrile Benzonitrile, 2-amino-4-chloro- 5-Chloro-2-cyanoaniline EINECS 253-967-8 (CAS 38487-86-4)
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Recommended Standards
- 2-(5-Chloro-2-thiazolyl)acetonitrile (CAS 1289083-12-0)
- 2-Chloro-5-methylthiazole-4-carbonitrile (CAS 1379336-26-1)
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- Isopropyl Chlorosulfonate (CAS 36610-67-0)
- Benzyl (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) carbonate (CAS 58936-19-9)
- 6,7-Dimethoxy-2-{[(4-nitrophenyl)methyl]sulfanyl}-3-octyl-3,4-dihydroquinazolin-4-imine (CAS 860789-61-3)
- (4-Methoxypyridin-2-yl)methyl acetate (CAS 16665-37-5)
- 2-Iodo-N-mesitylacetamide (CAS 1344287-16-6)
- Darunavir Impurity 19 (CAS 1932353-11-1)
- [(2-{[2-(3-Chlorophenyl)ethyl]amino}-2-oxoethyl)-(phenyl)amino]acetic acid (CAS 1142205-02-4)
- 2,4,4-Trimethyl-N-propylpentan-2-amine (CAS 101495-75-4)
- N-Neopentylcyclopropanamine (CAS 1094641-81-2)
- N-Cycloheptyl-3-(4-methoxyphenyl)pyrrolidine-1-carboxamide (CAS 1396857-39-8)
- Peptide 431 (CAS CATO-CPTD788431)
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