Enrofloxacin EP Impurity E CAS 1369495-59-9
| CAS No. | 1369495-59-9 |
| Molecular Formula | C19H22ClN3O3 |
| Molecular Weight | 375.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Enrofloxacin EP Impurity E.
Enrofloxacin EP Impurity E (CAS 1369495-59-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22ClN3O3 and a molecular weight of 375.85 g/mol.
Enrofloxacin EP Impurity E (C19H22ClN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN3O3 |
| Molecular Weight | 375.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Enrofloxacin Standards
- Enrofloxacin Impurity 5 (CAS CATO-C4X-16285)
- Enrofloxacin Methyl Ester (CAS 107884-20-8)
- Enrofloxacin Impurity 14 (CAS CATO-C4X-162814)
- Enrofloxacin-d5 (CAS 1173021-92-5)
- Enrofloxacin-d5 Hydrochloride (CAS CATO-LLAD300660)
- Enrofloxacin Ethyl Ester (CAS 107884-19-5)
- Enrofloxacin Impurity 9 (CAS CATO-C4X-16289)
- Enrofloxacin (CAS 93106-60-6)
Recommended Standards
- (E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)[(3-methylphenyl)methoxy]amine 478257-25-9 8P-664S (CAS 478257-25-9)
- N-aryl benzimidazole (CAS 422554-26-5)
- Bezafibrate EP Impurity C (CAS 2157488-46-3)
- 5-[(3-Chlorophenyl)sulfanyl]-N-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxamide (CAS 303998-08-5)
- Irbesartan Impurity 22 (CAS CATO-C4X-166622)
- Brexpiprazole Impurity 21 (CAS 2059954-32-2)
- Methylprednisolone Impurity 80 (CAS CATO-C4X-191980)
- 2-Azabicyclo[3.1.1]heptane-1-carbonitrile (CAS 1392879-18-3)
- (1E)-1-(Dimethylamino)-4-methylpent-1-en-3-one (CAS 5782-56-9)
- 3,3-Dimethyl-5-oxo-5-(pyrrolidin-1-yl)pentanoic acid (CAS 20129-56-0)
- 5-(5-Chloro-2-methoxyphenyl)furan-2-carbaldehyde (CAS 853314-04-2)
- Trimethyl(3-methyl-1-butyn-1-yl)silane (CAS 18388-07-3)
- 2,2-difluoro-1-[3-(propan-2-yloxy)phenyl]ethan-1-ol (CAS 1503138-13-3)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
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