Brexpiprazole Impurity 21 CAS 2059954-32-2
| CAS No. | 2059954-32-2 |
| Molecular Formula | C17H21Cl2NO2 |
| Molecular Weight | 342.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Brexpiprazole Impurity 21 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Brexpiprazole Impurity 21 (CAS 2059954-32-2) is a certified pharmaceutical impurity reference standard with the molecular formula C17H21Cl2NO2 and a molecular weight of 342.26 g/mol.
The molecular framework of Brexpiprazole Impurity 21 (C17H21Cl2NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Brexpiprazole Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H21Cl2NO2 |
| Molecular Weight | 342.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Brexpiprazole Standards
- Brexpiprazole Impurity 22 (CAS 2060027-95-2)
- Brexpiprazole Impurity 37 (CAS CATO-C4X-113137)
- Brexpiprazole Impurity 131 (CAS CATO-C4X-1131131)
- Brexpiprazole Impurity 83 (CAS 2295935-56-5)
- Brexpiprazole Impurity 84 (CAS CATO-C4X-113184)
- Brexpiprazole Impurity 138 (CAS CATO-C4X-1131138)
- Brexpiprazole Impurity 134 (CAS CATO-C4X-1131134)
- Brexpiprazole impurity 113 (CAS 2126178-13-8)
Recommended Standards
- NBD-Fructose (CAS 940961-04-6)
- N,N-Bis(4-chlorophenyl)-2,4-dimethylaniline (CAS 228718-48-7)
- 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one (CAS 314742-00-2)
- Avatrombopag Impurity 15 (CAS CATO-C4X-223415)
- Aztreonam impurity 64 (CAS CATO-C4X-152264)
- Iomeprol Impurity 18 (CAS CATO-C4X-182018)
- Vonoprazan Impurity 147 (CAS 748810-25-5)
- 2-amino-6-bromo-benzaldehyde (CAS 135484-74-1)
- 2-(Cyclopropylmethyl)-4-hydroxy-N,N-dimethylbenzamide (CAS 1243286-47-6)
- Methyl 2-(2-((4-chlorophenyl)sulfonamido)thiazol-4-yl)acetate (CAS 929808-62-8)
- 4-Hydroxy-1-(3,3,3-trifluoropropanoyl)piperidine-4-carbonitrile (CAS 2022446-49-5)
- 7-Bromo-5-iodobenzo[d]oxazole (CAS 1845689-86-2)
- Ramosetron Impurity 21 (CAS CATO-C4X-118221)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
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