Mitoxantrone EP Impurity D CAS 137132-70-8
| CAS No. | 137132-70-8 |
| Molecular Formula | C22H26N4O6 |
| Molecular Weight | 442.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Mitoxantrone EP Impurity D (CAS 137132-70-8, C22H26N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Mitoxantrone EP Impurity D (C22H26N4O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26N4O6 |
| Molecular Weight | 442.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 4 |
Related Mitoxantrone Standards
- Mitoxantrone (CAS 65271-80-9)
- Mitoxantrone Impurity 5 (CAS CATO-C4X-10345)
- Mitoxantrone Impurity 13 (CAS 70476-74-3)
- Mitoxantrone-d (CAS 1189974-82-0)
- Mitoxantrone EP Impurity B (CAS 80189-44-2)
- Mitoxantrone Impurity 19 (CAS CATO-C4X-103419)
- Mitoxantrone Impurity 22 (CAS CATO-C4X-103422)
- Mitoxantrone Impurity 16 (CAS CATO-C4X-103416)
Recommended Standards
- 2,2'-Diethoxy-[1,1'-binaphthalene]-4,4',6,6'-tetracarbonitrile (CAS 1255791-66-2)
- (E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]acrylic Acid (CAS 1639042-08-2)
- Fmoc-D-Oia-OH (CAS 2411591-46-1)
- Methyl 3-{[(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl]amino}benzoate (CAS 1796916-18-1)
- Vitamin K1 Impurity N1 (CAS CATO-C1803497)
- Bisoprolol EP Impurity C DiHCl (CAS 1225195-70-9 (free base))
- Lifitegrast Impurity 104 (CAS CATO-C4X-2409104)
- 1-(2-Cyclopropyl-5,6-dimethylpyrimidin-4-yl)-1H-imidazole-4-carboxylic acid (CAS 1707375-77-6)
- 2-(carboxymethyl)thiophene-3-carboxylic acid (CAS 332013-53-3)
- n-(Pyrimidin-5-ylmethyl)cyclohexanamine (CAS 1339341-94-4)
- 3-Bromo-2,5-difluoro-4-iodoaniline (CAS 2852766-94-8)
- 24398-88-7 3-BROMOBENZOIC ACID ETHYL ESTER AS03589 Ethyl 3-bromobenzoate M-BROMO BENZOIC ACID ETHYL ESTER RARECHEM AL BI 0052 (CAS 24398-88-7)
- 5-((5-Methyl-1h-pyrazol-1-yl)methyl)-4-((tetrahydrofuran-2-yl)methyl)-4h-1,2,4-triazole-3-thiol (CAS 1005651-99-9)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
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