Mitoxantrone EP Impurity B CAS 80189-44-2
| CAS No. | 80189-44-2 |
| Molecular Formula | C22H28N4O5 |
| Molecular Weight | 428.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 428.48 g/mol gives Mitoxantrone EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Mitoxantrone EP Impurity B (CAS 80189-44-2), a pharmacopoeial impurity reference standard (molecular formula C22H28N4O5, MW 428.48 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Mitoxantrone EP Impurity B (C22H28N4O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Mitoxantrone EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28N4O5 |
| Molecular Weight | 428.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 4 |
Related Mitoxantrone Standards
- Mitoxantrone Impurity 16 (CAS CATO-C4X-103416)
- Mitoxantrone Impurity 17 (CAS CATO-C4X-103417)
- Mitoxantrone EP Impurity D (CAS 137132-70-8)
- Mitoxantrone (CAS 65271-80-9)
- Mitoxantrone Impurity 5 (CAS CATO-C4X-10345)
- Mitoxantrone Impurity 13 (CAS 70476-74-3)
- Mitoxantrone-d (CAS 1189974-82-0)
- Mitoxantrone Impurity 19 (CAS CATO-C4X-103419)
Recommended Standards
- Xanthine Amine Congener (CAS 96865-92-8)
- Telmisartan EP Impurity E (CAS 884330-12-5)
- Tetrabutyl 1,3-trimethylenediphosphonate (CAS 64630-19-9)
- Oseltamivir glucose adduct-2 (CAS CATO-C4X-172048)
- Empagliflozin Impurity 169 (CAS 637-87-6)
- Olopatadine Impurity 30 (CAS 728-97-2)
- Itraconazole Impurity 97 (CAS CATO-C4X-149797)
- 1-(4-Fluorophenyl)-2-phenylquinazolin-4(1H)-one (CAS 1098-24-4)
- Indacaterol Impurity 92 (CAS CATO-C4X-150092)
- tert-Butyl (1-(4-bromophenyl)propyl)carbamate (CAS 1338547-18-4)
- Arbidol Impurity 26 (CAS CATO-C4X-112926)
- Carboxyamidotriazole (CAS 99519-84-3)
- Batrachotoxin (CAS 23509-16-2)
- D-β-Asp9-Tirzepatide (CAS CATO-CPTD788932)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com