Cefdinir Impurity 81 CAS 137171-77-8
| CAS No. | 137171-77-8 |
| Molecular Formula | C13H17ClN2O3 |
| Molecular Weight | 284.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Cefdinir Impurity 81 (C13H17ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Cefdinir Impurity 81 (CAS 137171-77-8) is a certified pharmaceutical impurity reference standard with the molecular formula C13H17ClN2O3 and a molecular weight of 284.74 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cefdinir Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17ClN2O3 |
| Molecular Weight | 284.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cefdinir Standards
- Cefdinir Impurity 53 (CAS 178422-40-7)
- Cefdinir USP Impurity A (CAS 178949-03-6)
- Cefdinir Impurity 40 (CAS 1330164-22-1)
- Cefdinir CP Impurity C (CAS 79349-82-9)
- Cefdinir Impurity 37 (CAS CATO-C4X-121037)
- Cefdinir Impurity 74 (CAS CATO-C4X-121074)
- Cefdinir Impurity 72 (CAS CATO-C4X-121072)
- Cefdinir Impurity 38 (CAS 37155-50-3)
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