Flurbiprofen impurity 120 CAS 87657-78-1
| CAS No. | 87657-78-1 |
| Molecular Formula | C15H14FNO |
| Molecular Weight | 243.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Flurbiprofen impurity 120 (C15H14FNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Flurbiprofen impurity 120 (CAS 87657-78-1) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14FNO and a molecular weight of 243.28 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flurbiprofen impurity 120 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14FNO |
| Molecular Weight | 243.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Flurbiprofen Standards
- Flurbiprofen impurity 119 (CAS CATO-C4X-1444119)
- Flurbiprofen Impurity 160 (CAS 607361-34-2)
- Flurbiprofen Impurity 161 (CAS CATO-C4X-1444161)
- (R)-Flurbiprofen (CAS 51543-40-9)
- (S)-Flurbiprofen (CAS 51543-39-6)
- Flurbiprofen Impurity 80 (CAS CATO-C4X-144480)
- Flurbiprofen (CAS 5104-49-4)
- Flurbiprofen Impurity 158 (CAS CATO-C4X-1444158)
Recommended Standards
- Glipizide Impurity 43 (CAS CATO-C4X-140743)
- Gliclazide EP Impurity C (CAS 5577-13-9)
- Cefotaxime Impurity 39 (CAS CATO-C4X-120139)
- Timolol Impurity 14 (CAS 58827-68-2)
- Rapamycin Impurity 11 (CAS 159351-88-9)
- Baloxavir Marboxil Impurity 184 (CAS 2417354-05-1)
- Chlorthalidone Impurity 15 (CAS 956-92-3)
- Lenalidomide Impurity 42 (CAS 1063995-49-2)
- 3-(2-(Pyridin-2-yl)ethoxy)aniline (CAS 915923-13-6)
- (Z)-4-((3-ethynylphenyl)amino)-4-oxobut-2-enoic acid (CAS 951166-01-1)
- 4-Amino-2-(difluoromethyl)-5-nitropyridine-3-sulfonyl chloride (CAS 1805014-71-4)
- (2-Chloro-7-fluoroquinolin-3-yl)methanol (CAS 1017429-31-0)
- 3-(5-Ethyl-4-methylthiophene-2-carboxamido)propanoic acid (CAS 1098380-63-2)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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