(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)methanol CAS 1373921-08-4
| CAS No. | 1373921-08-4 |
| Molecular Formula | C9H8F4O |
| Molecular Weight | 208.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)methanol (CAS 1373921-08-4) is a high-purity analytical reference standard with the molecular formula C9H8F4O and a molecular weight of 208.15 g/mol.
The molecular framework of (4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)methanol (C9H8F4O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F4O |
| Molecular Weight | 208.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 2-(4-Fluoro-2-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1000521-36-7)
- 2-(5-Fluoro-2-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1000528-45-9)
- 2-(3-Fluoro-4-(trifluoromethyl)phenyl)ethan-1-ol (CAS 1000560-90-6)
- 2-(3-fluoro-4-nitrophenyl)oxazole (CAS 1192720-18-5)
- 4-Fluoro-3-methyl-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1251084-39-5)
- 2-Fluoro-4-(1H-tetrazol-5-yl)benzoic acid (CAS 1281983-77-4)
- (2-Fluoro-5-methyl-4-(trifluoromethyl)phenyl)methanol (CAS 1323966-16-0)
- 5-Fluoro-2-methyl-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1341639-61-9)
Recommended Standards
- 7-Fluoro-6-nitroquinazolin-4-amine (CAS 1363151-62-5)
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- 2-(3-Fluoropyridin-2-yl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1431728-45-8)
- Methyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthoate (CAS 1290056-71-1)
- 7-(4-Iodobutoxy)-3,4-dihydroquinolin-2-one-d8 (CAS 1346599-53-8)
- (5-Chloro-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)methanol (CAS 2231675-83-3)
- 2-(Allylthio)-4-(phenylthio)thieno[3,2-d]pyrimidine (CAS 478067-58-2)
- N-(1H-Pyrrolo[2,3-b]pyridin-6-yl)acetamide (CAS 1000341-56-9)
- 1-(2-Methoxybenzyl)piperidin-4-ol (CAS 414873-43-1)
- Vancomycin EP Impurity B (CAS 555598-85-1)
- n-(cyclopropylmethyl)-2-(1h-indol-3-yl)ethan-1-amine hydrochloride (CAS 55330-13-7)
- [4-(hexyloxy)phenyl]methanol (CAS 3256-38-0)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
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