4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester CAS 1374639-78-7
| CAS No. | 1374639-78-7 |
| Molecular Formula | C28H38N8O3 |
| Molecular Weight | 534.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester (CAS 1374639-78-7) is a high-purity analytical reference standard with the molecular formula C28H38N8O3 and a molecular weight of 534.65 g/mol.
4-[6-(7-Cyclopentyl-6-dimethylcarbamoyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester (C28H38N8O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H38N8O3 |
| Molecular Weight | 534.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 8 |
Related Cyclopentyl Standards
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Recommended Standards
- (1R,2S)-2-[3-[(1E)-2-[4-[[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5'-methoxy-spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one (CAS 1338806-73-7)
- 9-(Naphthalen-2-yl)-9'-phenyl-9H,9'H-3,3'-bicarbazole (CAS 1454567-04-4)
- A12B4C3 (CAS 1005129-80-5)
- N-(4-Acetamidophenyl)-2-((3-(4-methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 477330-70-4)
- 2-Chloro-n-cyclopropyl-5-nitropyrimidin-4-amine (CAS 918889-15-3)
- (3,4-Dichlorophenyl)(2-(pyrrolidin-1-ylmethyl)phenyl)methanone (CAS 898774-99-7)
- (3-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)boronic acid (CAS 1443986-87-5)
- 1-Bromo-3-chloro-5-(2-methoxyethoxy)benzene (CAS 1345471-20-6)
- 4-Fluoro-3-nitro-1H-pyrrolo[2,3-c]pyridine (CAS 1190323-04-6)
- Ethyl 2-(3,6-dihydro-2H-pyran-4-yl)-2-nitroacetate (CAS 921755-40-0)
- 3-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-1-(naphthalen-1-ylsulfonyl)-1H-pyrazole (CAS 477709-68-5)
- N-isopentyl-4-methylphthalazin-1-amine (CAS 1153508-86-1)
- 2-((5-Benzyl-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-cyano-4,5-dimethylthiophen-2-yl)acetamide (CAS 332935-91-8)
- Semaglutide impurity 86 (CAS CATO-C4X-152686)
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