2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine CAS 1375472-56-2

Purity 97%+In StockPharmaceutical Standards
CAS No.1375472-56-2
Molecular FormulaC12H8ClF3N2O2
Molecular Weight304.65 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine CAS 1375472-56-2 chemical structure

Description

The occurrence of 2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies 2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine (CAS 1375472-56-2), a certified reference material (molecular formula C12H8ClF3N2O2, MW 304.65 g/mol) for analytical method development and quality control.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 304.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC12H8ClF3N2O2
Molecular Weight304.65 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1991
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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