3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-2-methyl-1,4-dihydropyridin-4-one CAS 303151-84-0
| CAS No. | 303151-84-0 |
| Molecular Formula | C12H8ClF3N2O2 |
| Molecular Weight | 304.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-2-methyl-1,4-dihydropyridin-4-one (CAS 303151-84-0), a certified reference material (molecular formula C12H8ClF3N2O2, MW 304.65 g/mol) for analytical method development and quality control.
The molecular framework of 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-2-methyl-1,4-dihydropyridin-4-one (C12H8ClF3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF3N2O2 |
| Molecular Weight | 304.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 4-{[4-chloro-3-(trifluoromethyl)-1h-pyrazol-1-yl]methyl}benzoic acid (CAS 1006455-35-1)
- Ethyl 4-chloro-7-(trifluoromethyl)quinazoline-2-carboxylate (CAS 1189106-05-5)
- Ethyl 4-chloro-6-(trifluoromethyl)quinazoline-2-carboxylate (CAS 1211533-94-6)
- 2-Chloro-6-{[3-(trifluoromethoxy)phenyl]methoxy}pyrazine (CAS 1375472-56-2)
- Ethyl 3-chloro-7-(trifluoromethyl)quinoxaline-2-carboxylate (CAS 194423-79-5)
- Ethyl 3-chloro-6-(trifluoromethyl)quinoxaline-2-carboxylate (CAS 194423-80-8)
- Ethyl 4-chloro-8-(trifluoromethyl)quinazoline-2-carboxylate (CAS 2112917-48-1)
- N-(4-chloro-3-methylisoxazol-5-yl)-3-(trifluoromethyl)benzamide (CAS 478262-53-2)
Recommended Standards
- 1-Methyl-5-phenoxy-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride (CAS 921939-09-5)
- 5-(3-Chlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 282523-36-8)
- 5-(4-Chlorophenoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 321848-47-9)
- 2-Methyl-5-(4-trifluoromethoxy-phenyl)-furan-3-carbonyl chloride (CAS 1858242-00-8)
- 2-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)pyridine (CAS 1805316-42-0)
- 4-Butoxy-2-chloro-1-fluorobenzene (CAS 1881331-19-6)
- Methyl 6-Fluorochroman-2-carboxylate (CAS 874649-82-8)
- 2-Amino-4-methoxybutan-1-ol (CAS 1314909-08-4)
- 2-((4,5-Dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one (CAS 1036069-26-7)
- (1-Methoxycyclooctyl)methanamine (CAS 326487-86-9)
- 4-(5-Ethylthiophen-2-yl)-5-methylthiazol-2-amine (CAS 781574-99-0)
- 1,3-Dilinoleoyl-2-chloropropanediol (CAS 1432592-04-5)
- 5-Hydroxybenzofuran-4,7-dione (CAS 90348-37-1)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com