6-Chloro-N-(4-fluorophenyl)picolinamide CAS 137640-94-9
| CAS No. | 137640-94-9 |
| Molecular Formula | C12H8ClFN2O |
| Molecular Weight | 250.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Chloro-N-(4-fluorophenyl)picolinamide (CAS 137640-94-9), molecular formula C12H8ClFN2O and molecular weight 250.66 g/mol, is a CATO reference standard with documented purity and traceability.
6-Chloro-N-(4-fluorophenyl)picolinamide (C12H8ClFN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Chloro-N-(4-fluorophenyl)picolinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFN2O |
| Molecular Weight | 250.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-N-(3-fluorophenyl)isonicotinamide (CAS 1019323-09-1)
- 2-Chloro-N-(4-fluorophenyl)isonicotinamide (CAS 1019383-51-7)
- 2-Chloro-N-(2-fluorophenyl)isonicotinamide (CAS 1019466-42-2)
- Methyl 2-Chloro-5-sulfamoylnicotinate (CAS 1118787-24-8)
- 5-(3-Chloro-2-fluorophenyl)nicotinamide (CAS 1125445-55-7)
- n-(4-Chloro-2-nitrophenyl)methanesulfonamide (CAS 1249400-38-1)
- n-(2-Chloro-6-nitrophenyl)methanesulfonamide (CAS 1339907-56-0)
- 5-(4-Chloro-2-fluorophenyl)nicotinamide (CAS 1346691-88-0)
Recommended Standards
- 4-Chloro-N-methyl-3-nitrobenzene-1-sulfonamide (CAS 137-48-4)
- methyl 6-chloro-5-sulfamoylpyridine-3-carboxylate (CAS 1803582-37-7)
- N-(4-chloro-3-nitrophenyl)methanesulfonamide (CAS 135937-15-4)
- (Chloromethyl)diphenylphosphine oxide (CAS 1806-49-1)
- 3-[(5Z)-5-[(3-Methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid (CAS 303793-09-1)
- Methyl 2-(propan-2-yloxy)pyridine-3-carboxylate (CAS 1030829-05-0)
- Mebrofenin CRS (CAS 78266-06-5)
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- 2-(1-Indazol-1-yl)ethan-1-amine (CAS 90887-04-0)
- (Z)-2-(4-(tert-Butyl)benzylidene)-6-hydroxy-7-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)benzofuran-3(2H)-one (CAS 1177494-33-5)
- N-(2,4-dichlorophenyl)-3-methyl-2,3-dihydro-1H-imidazole-4-carboxamide (CAS 866154-56-5)
- 1-(5-Bromo-4-methylthiazol-2-yl)guanidine (CAS 175136-87-5)
- Methyl 2-(4-amino-1H-imidazol-1-yl)-2-methylpropanoate (CAS 865775-54-8)
- Tau Peptide (512-525) amide trifluoroacetate salt (CAS 2022956-61-0)
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