3-Chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide CAS 1377997-28-8
| CAS No. | 1377997-28-8 |
| Molecular Formula | C27H28ClN5O2 |
| Molecular Weight | 490.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-Chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide (CAS 1377997-28-8), molecular formula C27H28ClN5O2 and molecular weight 490.00 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide (C27H28ClN5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C27H28ClN5O2 |
| Molecular Weight | 490.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Chloro Standards
- 7-(2-Chloro-5-methoxyphenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine (CAS 867331-63-3)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-((4-pentylphenyl)sulfonyl)-1,4-diazepane (CAS 646456-06-6)
- (E)-6-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-((4-(dimethylamino)benzylidene)amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (CAS 338761-72-1)
- 1-({2-[(2-chloro-1,3-thiazol-5-yl)methoxy]phenyl}methyl)-4-(diphenylmethyl)piperazine (CAS 866149-65-7)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N,N'-bis[(4-methylphenyl)methyl]propanediamide (CAS 478063-76-2)
- 4'-(4-Chloro-3-nitrophenyl)-1'-methyldispiro[chromane-3,3'-pyrrolidine-2',3''-indoline]-2'',4-dione (CAS 1177601-98-7)
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- N-((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-4-methoxy-N-(4-methoxyphenyl)benzenesulfonamide (CAS 955975-53-8)
Recommended Standards
- N-(2-((3-(4-Chlorobenzamido)phenyl)amino)-2-oxoethyl)-N-cyclohexylbenzamide (CAS 337505-71-2)
- 2,5,6-Trimethyl-7-(2,4,6-tribromophenyl)-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one (CAS 291539-89-4)
- 3-((4-Chlorophenyl)sulfonyl)-2-(cyclohexylsulfonyl)-4-methyl-6-phenylpyridine (CAS 339103-37-6)
- H-His(1-Trt)-OtBu (CAS 304698-96-2)
- Bis(3-methylbutyl) N-(2,2,3,3,4,4,4-heptafluorobutanoyl)aspartate (CAS 75743-06-5)
- 6-(Trifluoromethoxy)pyridine-3,4-diamine (CAS 1361850-78-3)
- tert-Butyl (3-(2-(2-hydroxyethoxy)ethoxy)propyl)carbamate (CAS 801239-88-3)
- UGH-2 (CAS 40491-34-7)
- tert-Butyl octahydrofuro[3,2-c]pyridine-5-carboxylate (CAS 1360363-67-2)
- Bis(4,4,4-trifluorobut-1-yl)amine (CAS 84138-09-0)
- 4-bromo-5-fluoro-3-methyl-1H-pyrazolo[3,4-b]pyridine (CAS 2765271-62-1)
- 2-(Ethylamino)propanamide (CAS 225229-01-6)
- Direct Violet 1 (CAS 2586-60-9)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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