Brimonidine Impurity 21 CAS 1378255-24-3
| CAS No. | 1378255-24-3 |
| Molecular Formula | C8H6BrN3 |
| Molecular Weight | 224.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Brimonidine Impurity 21 (CAS 1378255-24-3, C8H6BrN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H6BrN3, Brimonidine Impurity 21 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 224.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BrN3 |
| Molecular Weight | 224.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Brimonidine Standards
- Brimonidine EP Impurity B (CAS 50358-63-9)
- Brimonidine EP Impurity A (CAS 91147-43-2)
- Brimonidine Impurity 23 (CAS CATO-C4X-156623)
- Brimonidine Impurity 27 (CAS 185312-10-1)
- Brimonidine Impurity 32 (CAS CATO-C4X-156632)
- Brimonidine Impurity 25 (CAS 135306-57-9)
- Brimonidine Impurity 15 (CAS 91147-46-5)
- Brimonidine Impurity 24 (CAS CATO-C4X-156624)
Recommended Standards
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- 918811-38-8 6-Bromophthalazin-1-amine DTXSID70733171 (CAS 918811-38-8)
- Teprenone Impurity 24 (CAS CATO-C4X-208124)
- Nortriptyline EP Impurity F-d3 HCl (CAS 342611-00-1)
- Eperisone Impurity 43 (CAS CATO-C4X-227943)
- 1-((5-Methylfuran-2-yl)methyl)aziridine (CAS 193202-85-6)
- Cephalexin Impurity 34 (CAS CATO-C4X-126134)
- 4-((4-Aminophenyl)imino)-1-phenyl-1H-pyrazol-5(4H)-one (CAS 88779-05-9)
- 4'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid (CAS 59748-18-4)
- 4-Ethoxy-5-fluoro-2,6-dioxohexahydropyrimidine-5-carbonitrile (CAS 65906-82-3)
- 1-Cyclohexyldihydropyrimidine-2,4(1H,3H)-dione (CAS 712-42-5)
- Tirzepatide (CAS 2023788-19-2)
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