4-Ethynyl-6-(trifluoromethyl)pyrimidine CAS 1378258-80-0
| CAS No. | 1378258-80-0 |
| Molecular Formula | C7H3F3N2 |
| Molecular Weight | 172.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Ethynyl-6-(trifluoromethyl)pyrimidine (CAS 1378258-80-0), molecular formula C7H3F3N2 and molecular weight 172.11 g/mol, is a CATO reference standard with documented purity and traceability.
4-Ethynyl-6-(trifluoromethyl)pyrimidine (C7H3F3N2) contains a nitrile group, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Ethynyl-6-(trifluoromethyl)pyrimidine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H3F3N2 |
| Molecular Weight | 172.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ethynyl Standards
- 5-Ethynyl-2-(trifluoromethyl)pyrimidine (CAS 1196153-54-4)
- 2-Ethynyl-5-(trifluoromethyl)pyrimidine (CAS 1196153-58-8)
- 2-Ethynyl-5-(trifluoromethyl)pyrazine (CAS 1211580-74-3)
- 2-Ethynyl-4-(trifluoromethyl)pyrimidine (CAS 1698055-59-2)
- 4-Ethynyl-2-(trifluoromethyl)pyrimidine (CAS 37972-21-7)
- 2-Ethynyl-5-nitrobenzonitrile (CAS 1260794-78-2)
- 4-Ethynyl-3-nitrobenzonitrile (CAS 914105-97-8)
- 2-Ethynyl-6-methoxybenzofuran (CAS 1220972-70-2)
Recommended Standards
- 3-Cyano-4-(trifluoromethyl)pyridine (CAS 13600-43-6)
- 4-Fluoro-3,5-dihydroxybenzoic acid (CAS 1378521-08-4)
- Cerium IV Oxide (CAS 1306-38-3)
- 3-Fluoro-5-methyl-4-nitropyridine 1-oxide (CAS 13958-88-8)
- S-15176 difumarate salt (CAS 148913-55-7)
- 6-(Trifluoromethyl)-2,3,4,5-tetrahydropyridazin-3-one (CAS 628332-15-0)
- 2-(Difluoromethyl)-3-iodo-5-nitropyridine-6-methanol (CAS 1806023-58-4)
- Nε,Nε,Nε-Trimethyllysine-d9 (CAS 1182037-78-0)
- 1-(2-Chloro-4-hydroxy-7,8-dimethylquinolin-3-yl)ethanone (CAS 79074-98-9)
- Benzyl 1,2,3,4-tetrahydroquinoline-2-carboxylate (CAS 481001-67-6)
- Fluo-8 AM (CAS 1345980-40-6)
- Eravacycline impurity 18 (CAS CATO-C4X-293818)
- 7-Chloro-5,6-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine (CAS 890616-60-1)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com