Butylphthalide Impurity 71 CAS 1379356-37-2
| CAS No. | 1379356-37-2 |
| Molecular Formula | C8H4Br2O2 |
| Molecular Weight | 291.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Butylphthalide Impurity 71 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Butylphthalide Impurity 71 (CAS 1379356-37-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H4Br2O2 and a molecular weight of 291.92 g/mol.
Butylphthalide Impurity 71 (C8H4Br2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Butylphthalide Impurity 71 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4Br2O2 |
| Molecular Weight | 291.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
Related Butylphthalide Standards
- Butylphthalide Impurity 61 (CAS 40125-50-6)
- Butylphthalide Impurity 69 (CAS 879627-88-0)
- Butylphthalide Impurity 70 (CAS 102126-70-5)
- Butylphthalide Impurity N5 (CAS 169141-21-3)
- Butylphthalide Impurity 43 (CAS CATO-C4X-181343)
- Butylphthalide Impurity 29 (CAS CATO-C4X-181329)
- Butylphthalide Impurity 83 (CAS CATO-C4X-181383)
- Butylphthalide Impurity 36 (CAS 2245275-82-3)
Recommended Standards
- 5,7-Dibromo-1H-indazol-3-ol (CAS 108961-61-1)
- 3,3-Dibromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one (CAS 113423-51-1)
- 5,5'-Dibromo-2,2'-bifuran (CAS 70477-20-2)
- 3,6-Dibromoimidazo[1,2-a]pyrazin-8-amine (CAS 117718-87-3)
- Amisulpride Impurity 21 (CAS 59488-40-3)
- Tolperisone impurity 12 (CAS 59303-41-2)
- Loxoprofen impurity 85 (CAS 335096-46-3)
- N-Ethyl-N,N-dimethyldodecan-1-aminium chloride (CAS 1001-66-7)
- 1,3-thiazinan-2-one (CAS 14889-64-6)
- 3-Methyl-5-(1-tosylpiperidin-2-yl)pyridine (CAS 1352491-20-3)
- Telmesteine (CAS 122946-43-4)
- 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde (CAS 1311275-26-9)
- 2-Vinylnicotinaldehyde (CAS 893620-48-9)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
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